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There are no approved drugs containing it, and no legal basis for companies to claim it helps with pain or anxiety, according to the agency. Experts warn that means they will have stronger effects — and a greater risk for addiction and harm. “That creates a dangerous, addictive cycle where kratom use increases the craving for more use,” Volpicelli said. Last year, the Tampa Bay Times uncovered more than 580 kratom-related deaths in Florida alone since 2013. A Washington Post analysis found kratom listed in at least 4,100 deaths from 2020 to 2022. Just weeks prior to his death, Brandon Clarke was arrested for possession of kratom.

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Once dismissed as “unproven,” kratom is finally being recognized as a potential solution to one of America’s biggest health problems. In a PNN survey of over 6,000 kratom users, about one in ten said they used kratom as a treatment for OUD or alcoholism, with over 90% saying it was “very effective.” Many said kratom reduced their cravings and helped ween them from drugs. Although the main purpose of the placebo-controlled trial is to test the safety and tolerability of mitragynine – not whether it can treat OUD – the fact that NIH is even conducting such a study is being hailed as a “major milestone” by kratom advocates. In a small Phase One clinical study, NIH and University of Florida researchers will test a purified formulation of mitragynine on 32 healthy volunteers with a recent history of opioid use. Dive deep into this magic plant before you browse our online kratom store. These kratom strains are most often reported to have discomfort Relied / Pain relief like effects.

More recently, bills were introduced this 2025–26 legislative session in states like Delaware, Illinois, Michigan, South Dakota, and Tennessee that would prohibit kratom and kratom products within their boundaries. It is worth noting that states have generally considered several bills related to kratom in a single legislative session that offer different approaches to address the rising use of kratom and kratom-related products. Because of these effects and the ease with which the product can be purchased in retail settings, kratom has sometimes been referred to as “gas station heroin.” As concerns over the use of kratom continue to rise across the nation, the landscape of kratom policy has been evolving rapidly. Across the United States, state lawmakers are grappling with how—or whether—to regulate kratom, a plant-derived substance sold widely as powders, capsules, energy drinks, vapes, herbal supplements, and gummies in smoke shops, convenience stores, and online marketplaces. At the federal level, kratom is not a DEA-controlled substance, though the agency has weighed scheduling in the past.

• Councilman John Radford said the city has no means to do a partial regulation of kratom products through the regular testing of store products.
• “Vape stores are popping up in every neighborhood in America, and many are selling addictive products like concentrated 7-OH,” Makary warned.
• Some people have reported that kratom can help with self-treatment of opioid withdrawal symptoms.
• In a small Phase One clinical study, NIH and University of Florida researchers will test a purified formulation of mitragynine on 32 healthy volunteers with a recent history of opioid use.
• That’s why one kratom advocate was quick to point out that Clarke wasn’t arrested for “just kratom,” as he told deputies last April.
• States like Wisconsin, Indiana, Alabama, and Vermont had previously banned kratom, while states like Colorado and Mississippi had banned concentrated or synthetic 7-OH, allowing for the natural kratom leaf to continue to be sold.

Synthetic vs. Natural 7-OH: Why It Matters

“Once they started concentrating it in these 7-OH products, it was really replicating a full opioid,” she said. FORTUNE may receive compensation for some links to products and services on this website. Mac HaddowSenior Fellow on Public For more information, visit americankratom.org and learn more at kratomanswers.org. The American Kratom Association (AKA) will host a Congressional Briefing to cut through that confusion on one of the fastest growing and most misunderstood products in America.

Governor DeWine is asking the Ohio Board of Pharmacy to ban all natural chemical compounds in kratom, including mitragynine, 7-OH, and the less common but more potent compound mitragynine pseudoindoxyl (MP). For example, Tennessee has explicitly banned synthetic alkaloids while permitting natural plant products. According to agency statements, natural kratom leaf products are not the focus of this action. Most states regulate whole-leaf kratom through Kratom Consumer Protection Acts that set a 21+ age minimum, require accurate labeling, and prohibit adulterated or synthetic products. Despite their wide availability, kratom-derived and 7-OH products are not legally approved for sale for consumption online or in stores and are often misleadingly labeled and promoted as “safer" alternatives to opioids for the relief of pain and other issues.

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McCurdy said one issue is the various potencies of products that all call themselves kratom. Advocates for kratom say it has been a lifeline for many people who have struggled with chronic pain. One former MLS player who spent nearly a decade in the league said he thought of kratom as a healthy alternative to manage the pain of old injuries from his playing days.

Banning kratom is an option that several states are actively considering; this type of legislation would make the sale, possession, or manufacturing of kratom illegal throughout the state. These three buckets capture almost all the kratom-related bills that were under consideration in the 2025–26 state legislative sessions. Almost every state in the nation introduced some form of legislation regarding the status of kratom in its respective jurisdictions.

It quickly gained traction as a way of helping people get off of heroin or other opioids. Back then, we were still in what Stanciu characterizes as the “first wave” of kratom use here in the U.S. Kratom is usually advertised as a safe herbal supplement that’s used as an energy booster, pain reliever and, crucially, an aid for quitting opioids. Shelves festooned with kratom powders, capsules, liquids and extracts greet customers at Tifton Tobacco & Vapor in Tifton, Ga. For questions regarding this release or its content, contact for immediate assistance.